Sucrose alpha-glucosidase

Sucrose alpha-glucosidase
Identifiers
EC number 3.2.1.48
CAS number 37288-39-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sucrose alpha-glucosidase (EC 3.2.1.48, sucrose alpha-glucohydrolase, sucrase, sucrase-isomaltase, sucrose.alpha.-glucohydrolase, intestinal sucrase, sucrase(invertase)) is an enzyme with systematic name sucrose-alpha-D-glucohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action

This enzyme is isolated from intestinal mucosa as a single polypeptide chain.

References

  1. Conklin, K.A.; Yamashiro, K.M.; Gray, G.M. (1975). "Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits". J. Biol. Chem. 250: 5735–5741. PMID 807575.
  2. Hauri, H.P.; Quaroni, A.; Isselbacher, K.J. (1979). "Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase". Proc. Natl. Acad. Sci. USA. 76: 5183–5186. doi:10.1073/pnas.76.10.5183. PMID 291933.
  3. Kolinska, J.; Kraml, J. (1972). "Separation and characterization of sucrose-isomaltase and of glucoamylase of rat intestine". Biochim. Biophys. Acta. 284: 235–247. doi:10.1016/0005-2744(72)90062-9. PMID 5073761.
  4. Sigrist, H.; Ronner, P.; Semenza, G. (1975). "A hydrophobic form of the small-intestinal sucrase-isomaltase complex". Biochim. Biophys. Acta. 406: 433–446. doi:10.1016/0005-2736(75)90022-x. PMID 1182172.
  5. Sjöström, H.; Norén, O.; Christiansen, L.; Wacker, H.; Semenza, G. (1980). "A fully active, two-active-site, single-chain sucrase-isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein". J. Biol. Chem. 255: 11332–11338. PMID 7002920.
  6. Takesue, Y. (1969). "Purification and properties of rabbit intestinal sucrase". J. Biochem. (Tokyo). 65: 545–552. PMID 5804876.
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