Phenylpiperazine

Phenylpiperazine
Names


IUPAC name 1-phenylpiperazine
Identifiers
CAS Number	92-54-6^Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL9434^Y
ChemSpider	6829^Y
ECHA InfoCard	100.001.969
PubChem	7096
InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2^Y Key: YZTJYBJCZXZGCT-UHFFFAOYSA-N^Y InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 Key: YZTJYBJCZXZGCT-UHFFFAOYSA-N
SMILES c1cc(ccc1)N2CCNCC2
Properties
Chemical formula	C₁₀H₁₄N₂
Molar mass	162.23 g/mol
Appearance	clear colourless to yellow liquid
Density	1.028g/cm³
Melting point	18.8 °C (65.8 °F; 291.9 K)
Boiling point	287.2 °C (549.0 °F; 560.3 K) at 760mmHg
Solubility in water	insoluble
Hazards
Flash point	138.3 °C (280.9 °F; 411.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.^[1]

A number of phenylpiperazine derivatives are drugs, including:

Pharmaceuticals:

Antrafenine — anti-inflammatory
Aripiprazole — antipsychotic
Bifeprunox — antipsychotic
Brexpiprazole — antipsychotic
Cariprazine — antipsychotic
Ciprofloxacin — antibiotic
Dapiprazole — alpha blocker
Dropropizine — antitussive
Elopiprazole — antipsychotic
Etoperidone — antidepressant
Itraconazole — antifungal
Ketoconazole — antifungal
Levodropropizine — antitussive
Lubazodone — antidepressant
Mepiprazole — anxiolytic
Mianserin — antidepressant
Naftopidil — antihypertensive
Nefazodone — antidepressant
Niaprazine — hypnotic
Oxypertine — antipsychotic
Posaconazole — antifungal
Tioperidone — antipsychotic
Tolpiprazole (Tranquilliser)
Trazodone — antidepressant
Umespirone — antipsychotic
Urapidil — antihypertensive
Vesnarinone — cardiotonic

Research chemicals:

Acaprazine — anxiolytic
Batoprazine — serenic (antiaggressive)
Bifeprunox — antipsychotic
BRL-15,572 — serotonergic
CSP-2503 — anxiolytic
DMPP — nicotinic
EGIS-12,233 — serotonergic
Elopiprazole — antipsychotic
Eltoprazine — serenic
Enpiprazole — anxiolytic
Ensaculin — nootropic
Flibanserin — aphrodisiac
Fluprazine — serenic
Flesinoxan — antidepressant
Lorpiprazole — anxiolytic
Naluzotan — antidepressant
Naphthylpiperazine — serotonergic
Pardoprunox — antiparkinsonian
S-14,506 — serotonergic
S-14,671 — serotonergic
S-15,535 — serotonergic
SB-258,585 — serotonergic
SB-271,046 — serotonergic
SB-357,134 — serotonergic
SB-399,885 — serotonergic
Sonepiprazole — dopaminergic
Tolpiprazole — anxiolytic
Vilazodone — antidepressant
Vortioxetine — antidepressant
WAY-100,135 — serotonergic
WAY-100,635 — serotonergic
Zolertine — antihypertensive

Designer drugs:

DCPP — serotonergic
mCPP — serotonergic
MeOPP — serotonergic
pCPP — serotonergic
pFPP — serotonergic
TFMPP — serotonergic

References

↑ World Health Organization (WHO) (2006). "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved April 2010. Check date values in: |access-date= (help)

Piperazines

Simple piperazines (no additional rings)	1-Cyclohexylpiperazine Aminoethylpiperazine Diethylcarbamazine HEPPS Midafotel Piperazine PIPES

Phenylpiperazines	Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin CSP-2503 Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Naphthylpiperazine Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635

Benzylpiperazines	2C-B-BZP Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide Piberaline Piribedil Sunifiram Trimetazidine Vesnarinone

Diphenylalkylpiperazines (benzhydrylalkylpiperazines)	Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine Lidoflazine Manidipine Meclozine Oxatomide SNC-80 Vanoxerine

Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Prazitone Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone

Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine Pyridinylpiperazine

Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone

Tricyclics (piperazine attached via side chain)	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol

Others/Uncategorized	6-Nitroquipazine Azimilide Cinepazet Cinepazic acid Cinepazide Cyclohexylpiperazine Hexocyclium Indinavir JNJ-7777120 Lodenafil Mirodenafil PB-28 Quipazine Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VUF-6002 Zipeprol

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Phenylpiperazine

See also

References