Hydrogen dehydrogenase (NADP+)

hydrogen dehydrogenase (NADP+)
Identifiers
EC number 1.12.1.3
CAS number 9027-05-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a hydrogen dehydrogenase (NADP+) (EC 1.12.1.3) is an enzyme that catalyzes the chemical reaction

H2 + NADP+ H+ + NADPH

Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AUV.

References


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