Prostaglandin F receptor

PTGFR
Identifiers
Aliases PTGFR, FP, Prostaglandin F receptor
External IDs MGI: 97796 HomoloGene: 741 GeneCards: PTGFR
Targeted by Drug
tafluprost, bimatoprost, latanoprost, prostaglandin D2, dinoprostone, dinoprost, sulprostone, U46619[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5737

19220

Ensembl

ENSG00000122420

ENSMUSG00000028036

UniProt

P43088

P43117

RefSeq (mRNA)

NM_000959
NM_001039585

NM_008966

RefSeq (protein)

NP_000950.1
NP_001034674.1

NP_032992.1

Location (UCSC) Chr 1: 78.3 – 78.54 Mb Chr 3: 151.8 – 151.84 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F. It is encoded by the gene PTGFR.[4]

It is a member of the G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.[4]

Functions

Main effects of prostaglandin binding to the receptor are:

Via activation of this receptor, PGF2-alpha mediates luteolysis,[4] and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters.[6]

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.[7]

See also

References

  1. "Drugs that physically interact with Prostaglandin F2-alpha receptor view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. 1 2 3 "Entrez Gene: PTGFR prostaglandin F receptor (FP)".
  5. Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003) Page 234
  6. Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.
  7. Sugimoto Y, Yamasaki A, Segi E, et al. (1997). "Failure of parturition in mice lacking the prostaglandin F receptor". Science. 277 (5326): 681–3. doi:10.1126/science.277.5326.681. PMID 9235889.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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