Endomorphin-1
 | |
| Names | |
|---|---|
| IUPAC name
L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide | |
| Identifiers | |
| 189388-22-5 | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 4470614 |
| 1623 | |
| PubChem | 5311080e |
| |
| |
| Properties | |
| C34H38N6O5 | |
| Molar mass | 610.703 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Endomorphin-1 (EM-1) (amino acid sequence Tyr-Pro-Trp-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins.[1] It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-2 (EM-2), has been proposed to be the actual endogenous ligand of the μ-receptor.[1][2][3][4] EM-1 produces analgesia in animals and is equipotent with morphine in this regard.[3] The gene encoding for EM-1 has not yet been identified.[4]
See also
References
- 1 2 Richard J. Bodnar; Kathryn Grace Commons; Donald W. Pfaff (3 April 2002). Central Neural States Relating Sex and Pain. JHU Press. pp. 67–. ISBN 978-0-8018-6827-6.
- ↑ H.-J. Krammer; M.V. Singer (31 May 2000). Neurogastroenterology - From the Basics to the Clinics. Springer Science & Business Media. pp. 76–. ISBN 978-0-7923-8757-2.
- 1 2 Susan Brain; P.K. Moore (1999). Pain and Neurogenic Inflammation. Springer Science & Business Media. pp. 28–. ISBN 978-3-7643-5875-4.
- 1 2 Stefan Offermanns; Walter Rosenthal (14 August 2008). Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 904–. ISBN 978-3-540-38916-3.
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