Cutaneous small-vessel vasculitis

Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis", "Cutaneous leukocytoclastic vasculitis", "Cutaneous necrotizing venulitis" and "Hypersensitivity angiitis")^[1] is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura.^[2]^:831^[3] It is the most common vasculitis seen in clinical practice.

Leukocytoclasis refers to the damage caused by nuclear debris from infiltrating neutrophils in and around the vessels.^[4]

Subtypes of small-vessel vasculitis include:^[2]^:833–6

IgA vasculitis (Henoch-Schönlein purpura)^[5]
Acute hemorrhagic edema of infancy
Urticarial vasculitis
Cryoglobulinemic vasculitis
Erythema elevatum diutinum
Granuloma faciale

Leukocytoclastic vasculitis

References

↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
1 2 James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
↑ Lotti T, Ghersetich I, Comacchi C, Jorizzo JL (November 1998). "Cutaneous small-vessel vasculitis". J. Am. Acad. Dermatol. 39 (5 Pt 1): 667–87; quiz 688–90. doi:10.1016/S0190-9622(98)70039-8. PMID 9810883.
↑ Harrison's Principles of Internal Medicine. 18th edition. Page 2798.
↑ J. C. Jennette; R. J. Falk; P. A. Bacon; et al. (January 2013). "2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides". Arthritis & Rheumatism. 65 (1): 1–11. doi:10.1002/art.37715. PMID 23045170.

Cutaneous vasculitis and other vascular-related cutaneous conditions (L95, 709.1)

Cutaneous vasculitis	Erythema elevatum diutinum Capillaritis Urticarial vasculitis Nodular vasculitis

Microvascular occlusion	Calciphylaxis Cryoglobulinemic purpura/Cryoglobulinemic vasculitis vascular coagulopathy: Livedoid vasculitis Livedoid dermatitis Perinatal gangrene of the buttock Malignant atrophic papulosis Sneddon's syndrome

Purpura	Nonthrombocytopenic purpura: Cryofibrinogenemic purpura Drug-induced purpura Food-induced purpura IgA vasculitis Obstructive purpura Orthostatic purpura Purpura fulminans Purpura secondary to clotting disorders Purpuric agave dermatitis Pigmentary purpuric eruptions Solar purpura Traumatic purpura Waldenström hyperglobulinemic purpura Painful bruising syndrome ungrouped: Paroxysmal hand hematoma Postcardiotomy syndrome Deep vein thrombosis Superficial thrombophlebitis Mondor's disease Blueberry muffin baby Fibrinolysis syndrome

Systemic vasculitis	see Template:Systemic vasculitis

Vascular malformations	Arteriovenous malformation Bonnet–Dechaume–Blanc syndrome Cobb syndrome Parkes Weber syndrome Sinusoidal hemangioma lymphatic malformation Hennekam syndrome Aagenaes syndrome telangiectasia: Generalized essential telangiectasia Hereditary hemorrhagic telangiectasia Unilateral nevoid telangiectasia

Ulcer	Venous ulcer Arterial insufficiency ulcer Hematopoietic ulcer Neuropathic ulcer Acroangiodermatitis

Lymphedema	see Template:Lymphatic vessel disease

Ungrouped vascular-related cutaneous conditions	Raynaud's phenomenon Thromboangiitis obliterans Erythromelalgia Septic thrombophlebitis Arteriosclerosis obliterans Bier spots/Marshall–White syndrome Cholesterol embolus Reactive angioendotheliomatosis Trousseau's syndrome

Systemic vasculitis (M30–M31, 446)

Large vessel

Medium vessel

Small vessel

Pauci-immune	c-ANCA Granulomatosis with polyangiitis p-ANCA Eosinophilic granulomatosis with polyangiitis Microscopic polyangiitis

Type III hypersensitivity	Hypersensitivity vasculitis/IgA vasculitis

Ungrouped	Acute hemorrhagic edema of infancy Cryoglobulinemic vasculitis Bullous small vessel vasculitis Cutaneous small-vessel vasculitis

Other

Hypersensitivity and autoimmune diseases (279.5–6)

Type I/allergy/atopy
(IgE)

Foreign	Atopic eczema Allergic urticaria Allergic rhinitis (Hay fever) Allergic asthma Anaphylaxis Food allergy common allergies include: Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy

Autoimmune	Eosinophilic esophagitis

Type II/ADCC

- IgM
- IgG

Foreign

Hemolytic disease of the newborn

Autoimmune

Cytotoxic	Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture's syndrome Guillain–Barré syndrome

"Type V"/receptor	Graves' disease Myasthenia gravis Pernicious anemia

Type III
(Immune complex)

Foreign	Henoch–Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction

Autoimmune	Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis

Type IV/cell-mediated
(T cells)

Foreign	Allergic contact dermatitis Mantoux test

Autoimmune	Diabetes mellitus type 1 Hashimoto's thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis

GVHD	Transfusion-associated graft versus host disease

Unknown/
multiple

Foreign	Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy (I+IV)

Autoimmune	Sjögren's syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease

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Cutaneous small-vessel vasculitis

Leukocytoclastic vasculitis

See also

References