LILRB1

LILRB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1G0X, 1P7Q, 1UFU, 1UGN, 1VDG, 3D2U, 4LL9, 4NO0
Identifiers
Aliases	LILRB1, CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB, leukocyte immunoglobulin like receptor B1
External IDs	HomoloGene: 88463 GeneCards: LILRB1
Gene ontology Molecular function • protein homodimerization activity • MHC class I receptor activity • SH2 domain binding • protein phosphatase 1 binding • HLA-A specific inhibitory MHC class I receptor activity • HLA-B specific inhibitory MHC class I receptor activity • MHC class I protein binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • extracellular region • external side of plasma membrane Biological process • negative regulation of endocytosis • dendritic cell differentiation • negative regulation of mononuclear cell proliferation • negative regulation of interferon-gamma production • adaptive immune response • Fc receptor mediated inhibitory signaling pathway • negative regulation of osteoclast development • negative regulation of interferon-beta secretion • immune system process • negative regulation of transforming growth factor-beta secretion • response to virus • receptor internalization • negative regulation of cell cycle • negative regulation of cytokine secretion involved in immune response • negative regulation of serotonin secretion • T cell proliferation involved in immune response • negative regulation of interleukin-12 secretion • negative regulation of alpha-beta T cell activation • negative regulation of T cell mediated cytotoxicity • positive regulation of cytolysis • negative regulation of T cell proliferation • negative regulation of tumor necrosis factor biosynthetic process • positive regulation of gene expression • negative regulation of interleukin-10 secretion • defense response to virus • negative regulation of calcium ion transport • regulation of immune response • positive regulation of apoptotic process • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • interferon-gamma production • cellular response to lipopolysaccharide • interferon-gamma secretion • immune response-inhibiting cell surface receptor signaling pathway • positive regulation of gamma-delta T cell activation involved in immune response • negative regulation of dendritic cell apoptotic process • negative regulation of dendritic cell differentiation • negative regulation of interferon-gamma biosynthetic process • signal transduction • positive regulation of transcription from RNA polymerase II promoter • negative regulation of CD8-positive, alpha-beta T cell activation • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10859	n/a
Ensembl	n/a	n/a
UniProt	Q8NHL6	n/a
RefSeq (mRNA)	NM_001081637 NM_001081638 NM_001081639 NM_001278398 NM_001278399 NM_006669	n/a
RefSeq (protein)	NP_001075106.2 NP_001075107.2 NP_001075108.2 NP_001265327.2 NP_001265328.2 NP_006660.4	n/a
Location (UCSC)	Chr 19: 54.62 – 54.64 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.^[2][3]

Function

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

See also

• Cluster of differentiation

References

Further reading

External links

• LILRB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

PDB gallery
1g0x: CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF LIR-1 (ILT2)  1p7q: Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor  1ufu: Crystal structure of ligand binding domain of immunoglobulin-like transcript 2 (ILT2; LIR-1)  1ugn: Crystal structure of LIR1.02, one of the alleles of LIR1  1vdg: Crystal structure of LIR1.01, one of the alleles of LIR1