CXCR6

CXCR6
Identifiers
Aliases CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs MGI: 1934582 HomoloGene: 38197 GeneCards: CXCR6
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

10663

80901

Ensembl

ENSG00000172215

ENSMUSG00000048521

UniProt

O00574

Q9EQ16

RefSeq (mRNA)

NM_006564

NM_030712

RefSeq (protein)

NP_006555.1

NP_109637.3

Location (UCSC) Chr 3: 45.94 – 45.95 Mb Chr 9: 123.81 – 123.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[3][4][5] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[3][4][5][6] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[6] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334Freely accessible. PMID 9166430.
  4. 1 2 Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. doi:10.1038/40894. PMID 9230441.
  5. 1 2 "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".
  6. 1 2 Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357Freely accessible. PMID 26109719.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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