ZRANB2

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1N0Z, 2K1P, 3G9Y

Identifiers

Aliases

ZRANB2, ZIS, ZIS1, ZIS2, ZNF265, zinc finger RANBP2-type containing 2

External IDs

HomoloGene: 135921 GeneCards: ZRANB2

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • poly(A) RNA binding • zinc ion binding • protein binding • metal ion binding • RNA binding
Cellular component	• nucleus • nucleoplasm
Biological process	• mRNA processing • RNA splicing • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9406


n/a

Ensembl


ENSG00000132485


n/a

UniProt


O95218


n/a

RefSeq (mRNA)


NM_005455 NM_203350


n/a

RefSeq (protein)


NP_005446.2 NP_976225.1


n/a

Location (UCSC)

Chr 1: 71.06 – 71.08 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.^[2]^[3]

Interactions

ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1^[4] and SNRP70.^[4]

References

↑ "Human PubMed Reference:".
↑ Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (February 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene. 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.
↑ "Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2".
1 2 Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adams DJ, van der Weyden L, Kovacic A, Lovicu FJ, Copeland NG, Gilbert DJ, Jenkins NA, Ioannou PA, Morris BJ (2000). "Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene". Cytogenet. Cell Genet. 88 (1–2): 68–73. doi:10.1159/000015487. PMID 10773668.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987.
Plambeck CA, Kwan AH, Adams DJ, Westman BJ, van der Weyden L, Medcalf RL, Morris BJ, Mackay JP (2003). "The structure of the zinc finger domain from human splicing factor ZNF265 fold". J. Biol. Chem. 278 (25): 22805–22811. doi:10.1074/jbc.M301896200. PMID 12657633.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Mangs AH, Speirs HJ, Goy C, Adams DJ, Markus MA, Morris BJ (2006). "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265". Nucleic Acids Res. 34 (17): 4976–4986. doi:10.1093/nar/gkl660. PMC 1635291. PMID 16982639.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

ZRANB2 human gene location in the UCSC Genome Browser.
ZRANB2 human gene details in the UCSC Genome Browser.

PDB gallery

1n0z: Solution structure of the first zinc-finger domain from ZNF265

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

ZRANB2

Interactions

References

Further reading

External links