ZFYVE16

ZFYVE16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ZFYVE16, PPP1R69, zinc finger FYVE-type containing 16
External IDs MGI: 2145181 HomoloGene: 8826 GeneCards: ZFYVE16
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9765

218441

Ensembl

ENSG00000039319

ENSMUSG00000021706

UniProt

Q7Z3T8

Q80U44

RefSeq (mRNA)

NM_001105251
NM_001284236
NM_001284237
NM_014733

NM_173392

RefSeq (protein)

NP_001098721.1
NP_001271165.1
NP_001271166.1
NP_055548.3

NP_775568.1

Location (UCSC) Chr 5: 80.41 – 80.48 Mb Chr 13: 92.49 – 92.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.[3][4]

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM][4]

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.[5]

Interactions

ZFYVE16 has been shown to interact with TOM1.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Seet LF, Hong W (Nov 2001). "Endofin, an endosomal FYVE domain protein". J Biol Chem. 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
  4. 1 2 "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
  5. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  6. Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. United States. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

Further reading


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