YqeY protein domain

YqeY

Structure of cytosolic protein of unknown function YqeY from Bacillus subtilis
Identifiers
Symbol YqeY
Pfam PF09424
Pfam clan CL0279
InterPro IPR019004
SCOP 1ng5
SUPERFAMILY 1ng5

In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes.[1]

Function

The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine (tRNA-Gln).[1] In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis (that is, as part of the GlnRS polypeptide chain). However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.[2]

Homology

This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.[2]

References

  1. 1 2 Hadd, A; Perona, JJ (23 October 2014). "Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases.". Journal of molecular biology. 426 (21): 3619–33. doi:10.1016/j.jmb.2014.08.006. PMID 25149203.
  2. 1 2 Deniziak M, Sauter C, Becker HD, Paulus CA, Giegé R, Kern D (2007). "Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation.". Nucleic Acids Res. 35 (5): 1421–31. doi:10.1093/nar/gkl1164. PMC 1865053Freely accessible. PMID 17284460.
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