Diphenidol

Diphenidol
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration
Oral
ATC code none
Pharmacokinetic data
Biological half-life 4 hours
Identifiers
CAS Number 972-02-1 YesY
PubChem (CID) 9175
IUPHAR/BPS 7163
DrugBank DB01231 YesY
ChemSpider 2947 YesY
UNII NQO8R319LY YesY
KEGG D03858 YesY
ChEBI CHEBI:4638 YesY
ChEMBL CHEMBL936 YesY
ECHA InfoCard 100.012.310
Chemical and physical data
Formula C21H27NO
Molar mass 309.44518 g/mol
3D model (Jmol) Interactive image
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Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. - Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

References

DrugBank http://www.drugbank.ca/drugs/DB01231


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