VPRBP

DCAF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases DCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1
External IDs MGI: 2445220 HomoloGene: 8805 GeneCards: DCAF1
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez

9730

321006

Ensembl

ENSG00000145041

ENSMUSG00000040325

UniProt

Q9Y4B6

Q80TR8

RefSeq (mRNA)

NM_001171904
NM_014703

NM_001015507

RefSeq (protein)

NP_001165375.1
NP_055518.1

NP_001015507.1

Location (UCSC) Chr 3: 51.4 – 51.5 Mb Chr 9: 106.82 – 106.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.[3][4][5]

Interactions

VPRBP has been shown to interact with Merlin.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Zhao LJ, Mukherjee S, Narayan O (Jun 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". J Biol Chem. 269 (22): 15577–82. PMID 8195203.
  4. Zhang S, Feng Y, Narayan O, Zhao LJ (Mar 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1-2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
  5. "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
  6. Huang, J; Chen J (Jul 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. England. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading


This article is issued from Wikipedia - version of the 7/12/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.