Topogenic sequence

A topogenic sequence is a collective term used for a peptide sequence present at nascent proteins essential for their insertion and orienting in cellular membranes. The sequences are also used to translocate proteins across various intracellular membranes,[1] and ensure they are transported to the correct organelle after synthesis.[2] The position of the sequence may be at the end, e.g. N-terminal signal sequence, or in mid parts of the nascent protein, e.g. stop-transfer anchor sequences and signal-anchor sequences.[3] If the sequence is at the end of the polypeptide it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase and degraded.

As an example, the vast majority of all known complex plastid preproteins (an 'unactivated' protein) encoded in the nucleus possess a topogenic sequence.[2]

See also

References

  1. ↑ Robinson, A; Austen, B (1 September 1987). "The role of topogenic sequences in the movement of proteins through membranes.". Biochem J. 246 (2): 249–261.
  2. 1 2 Gould, Sven; Waller, R; McFadden, G (June 2008). "Plastid Evolution". Annual Review of Plant Biology. 59: 491–517. doi:10.1146/annurev.arplant.59.032607.092915. PMID 18315522.
  3. ↑ Lodish, Harvey (2013). Molecular Cell Biology. Macmillan Higher Education. pp. 587–588. ISBN 1-4292-3413-X.


This article is issued from Wikipedia - version of the 5/31/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.