TSFM

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CP9

Identifiers

Aliases

TSFM, EFTS, EFTSMT, Ts translation elongation factor, mitochondrial

External IDs

MGI: 1913649 HomoloGene: 4184 GeneCards: TSFM

Gene ontology
Molecular function	• poly(A) RNA binding • translation elongation factor activity
Cellular component	• mitochondrial matrix • intracellular • mitochondrion • nucleus
Biological process	• translational elongation • regulation of DNA-templated transcription, elongation • translation • mitochondrial translational elongation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10102


66399

Ensembl


ENSG00000123297


ENSMUSG00000040521

UniProt


P43897


Q9CZR8

RefSeq (mRNA)


NM_005726 NM_001172695 NM_001172696 NM_001172697


NM_025537

RefSeq (protein)


NP_001166166.1 NP_001166167.1 NP_001166168.1 NP_005717.3


NP_079813.1

Location (UCSC)

Chr 12: 57.78 – 57.81 Mb

Chr 10: 127.01 – 127.03 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Xin H, Woriax V, Burkhart W, Spremulli LL (Aug 1995). "Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver". J Biol Chem. 270 (29): 17243–9. doi:10.1074/jbc.270.29.17243. PMID 7615523.
↑ "Entrez Gene: TSFM Ts translation elongation factor, mitochondrial".

Smeitink JA, Elpeleg O, Antonicka H, et al. (2006). "Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs.". Am. J. Hum. Genet. 79 (5): 869–77. doi:10.1086/508434. PMC 1698578. PMID 17033963.
Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA (2006). "The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1.". Hum. Mol. Genet. 15 (11): 1835–46. doi:10.1093/hmg/ddl106. PMID 16632485.
Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID 16583711.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vernon JL, Burr PC, Wiley JE, Farwell MA (2000). "Assignment of the mitochondrial translation elongation factor Ts gene (TSFM) to human chromosome 12 bands q13→q14 by in situ hybridization and with somatic cell hybrids.". Cytogenet. Cell Genet. 89 (3–4): 145–6. doi:10.1159/000015596. PMID 10965106.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Benkowski LA, Takemoto C, Ott G, et al. (1996). "Interaction of mitochondrial elongation factors Tu.Ts with aminoacyl-tRNA". Nucleic Acids Symp. Ser. (33): 163–6. PMID 8643359.

External links

TSFM human gene location in the UCSC Genome Browser.
TSFM human gene details in the UCSC Genome Browser.

PDB gallery

2cp9: Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts

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TSFM

References

Further reading

External links