TRIM68

TRIM68
Identifiers
Aliases	TRIM68, GC109, RNF137, SS-56, SS56, tripartite motif containing 68
External IDs	MGI: 2142077 HomoloGene: 9991 GeneCards: TRIM68
Gene ontology Molecular function • zinc ion binding • ligase activity • androgen receptor binding • histone acetyltransferase binding • metal ion binding • ubiquitin-protein transferase activity Cellular component • cytoplasm • perinuclear region of cytoplasm • cytosol • Golgi apparatus • nucleolus • intracellular • nucleus Biological process • interferon-gamma-mediated signaling pathway • regulation of androgen receptor signaling pathway • protein ubiquitination • protein autoubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55128	101700
Ensembl	ENSG00000167333	ENSMUSG00000073968
UniProt	Q6AZZ1	Q8K243
RefSeq (mRNA)	NM_018073 NM_001304496	NM_198012 NM_001307998
RefSeq (protein)	NP_001291425.1 NP_060543.5	n/a
Location (UCSC)	Chr 11: 4.6 – 4.61 Mb	Chr 7: 102.68 – 102.69 Mb
PubMed search	[1]	[2]
Wikidata

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.^[3][4]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.^[4]

Interactions

TRIM68 has been shown to interact with Androgen receptor.^[5]

References

Further reading