TRIM3

TRIM3
Identifiers
Aliases	TRIM3, BERP, HAC1, RNF22, RNF97, tripartite motif containing 3
External IDs	MGI: 1860040 HomoloGene: 21290 GeneCards: TRIM3
Gene ontology Molecular function • zinc ion binding • protein C-terminus binding • protein binding • metal ion binding • ubiquitin protein ligase activity • ubiquitin-protein transferase activity Cellular component • cytoplasm • endosome • early endosome • intracellular Biological process • protein transport • protein ubiquitination • nervous system development • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10612	55992
Ensembl	ENSG00000110171	ENSMUSG00000036989
UniProt	O75382	Q9R1R2
RefSeq (mRNA)	NM_001248006 NM_001248007 NM_006458 NM_033278	NM_001285870 NM_001285871 NM_001285873 NM_018880
RefSeq (protein)	NP_001234935.1 NP_001234936.1 NP_006449.2 NP_150594.2	NP_001272799.1 NP_001272800.1 NP_001272802.1 NP_061368.1
Location (UCSC)	Chr 11: 6.45 – 6.47 Mb	Chr 7: 105.6 – 105.63 Mb
PubMed search	[1]	[2]
Wikidata

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.^[3][4]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.^[4]

Interactions

TRIM3 has been shown to interact with Actinin alpha 4.^[5]

References

Further reading