TRAPPC2

TRAPPC2
Identifiers
Aliases TRAPPC2, MIP2A, SEDL, SEDT, TRAPPC2P1, TRS20, ZNF547L, hYP38334, trafficking protein particle complex 2
External IDs MGI: 1913476 HomoloGene: 5436 GeneCards: TRAPPC2
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

6399

66226

Ensembl

ENSG00000196459

ENSMUSG00000079317

UniProt

P0DI81
P0DI82

Q9CQP2

RefSeq (mRNA)

NM_001011658
NM_001128835
NM_014563

NM_025432
NM_001313722

RefSeq (protein)

NP_001011658.1
NP_001122307.2
NP_055378.1
NP_001011658.1
NP_055378.1

NP_001300651.1
NP_079595.1
NP_079708.2

Location (UCSC) Chr X: 13.71 – 13.73 Mb Chr X: 166.44 – 166.45 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Trafficking protein particle complex subunit 2 (TRAPPC2) also known as MBP-1-interacting protein 2A (MIP-2A) is a protein that in humans is encoded by the TRAPPC2 gene.[3][4] A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes of it are found on chromosome 8 and the Y chromosome. Two transcript variants encoding the same protein have been found for this gene.[4]

Function

Trafficking protein particle complex subunit 2 is thought to be part of a large multisubunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability.[4]

Genetic Location

The TRAPPC2 gene is located on the X-chromosome at position 22 between base-pairs 13,712,241 to 13,734,634.[5]

Clinical significance

Mutations in this gene are a cause of X-linked spondyloepiphyseal dysplasia tarda (SEDT).[4]

Interactions

TRAPPC2 has been shown to interact with Alpha-enolase[6] and CLIC1.[7]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Gecz J, Shaw MA, Bellon JR, de Barros Lopes M (November 2003). "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not". Gene. 320: 137–44. doi:10.1016/S0378-1119(03)00819-9. PMID 14597397.
  4. 1 2 3 4 "Entrez Gene: TRAPPC2 trafficking protein particle complex 2".
  5. "TRAPPC2 gene at Genetics Home Reference".
  6. Ghosh, A K; Majumder M; Steele R; White R A; Ray R B (January 2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. UNITED STATES. 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. ISSN 0270-7306. PMC 86643Freely accessible. PMID 11134351.
  7. Fan, Libin; Yu Wei; Zhu Xueliang (April 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. Netherlands. 540 (1–3): 77–80. doi:10.1016/S0014-5793(03)00228-X. ISSN 0014-5793. PMID 12681486.

Further reading


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