TBCD

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TBCD
Identifiers
Aliases TBCD, SSD-1, tfcD, tubulin folding cofactor D
External IDs MGI: 1919686 HomoloGene: 4368 GeneCards: TBCD
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

6904

108903

Ensembl

n/a

ENSMUSG00000039230

UniProt

Q9BTW9

Q8BYA0

RefSeq (mRNA)

NM_001033052
NM_005993

NM_029878

RefSeq (protein)

NP_005984.3

NP_084154.1

Location (UCSC) Chr 17: 82.75 – 82.95 Mb Chr 11: 121.45 – 121.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.[3]

Function

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.[3]

Interactions

TBCD has been shown to interact with ARL2.[4][5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: TBCD tubulin folding cofactor D".
  4. Shern JF, Sharer JD, Pallas DC, Bartolini F, Cowan NJ, Reed MS, Pohl J, Kahn RA (October 2003). "Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A". J. Biol. Chem. 278 (42): 40829–36. doi:10.1074/jbc.M308678200. PMID 12912990.
  5. Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin". J. Cell Biol. 149 (5): 1087–96. doi:10.1083/jcb.149.5.1087. PMC 2174823Freely accessible. PMID 10831612.

Further reading


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