Small nucleolar SNORD12/SNORD106
| Small nucleolar SNORD12/SNORD106 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD12 | |
| Identifiers | |
| Symbol | SNORD12 |
| Alt. Symbols | SNORD106; snoHBII-99 |
| Rfam | RF00581 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000593 |
In molecular biology, the small nucleolar RNAs SNORD106 and SNORD12 (also known as U106 and HBII-99 respectively ) are two related snoRNAs which belongs to the C/D class of small nucleolar RNAs (snoRNAs). Both contain the conserved C (UGAUGA) and D (CUGA) box sequence motifs [1]
Human SNORD12 (HBII-99) is the homologue of mouse snoRNA MBII-99. In humans both HB11-99 and U106 snoRNAs share the same host gene.[2][3]
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. HBII-99 is predicted to guide the 2'O-ribose methylation of 28S rRNA G3878.[4] U106 contains conserved antisense elements which would predict U106 methylates residues G1536 and U1602 of 18S rRNA.[5] However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding.[2] A similar role has been suggested for the H/ACA snoRNAs U17a and U17b[2]
References
- ↑ Vitali, Patrice; Royo, Hélène; Seitz, Hervé; Bachellerie, Jean‐Pierre; Hüttenhofer, Alexander; Cavaillé, Jérôme (15 November 2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Research. 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545
. PMID 14602913. - 1 2 3 Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ↑ Askarian-Amiri, M. E.; Crawford, J.; French, J. D.; Smart, C. E.; Smith, M. A.; Clark, M. B.; Ru, K.; Mercer, T. R.; Thompson, E. R.; Lakhani, S. R.; Vargas, A. C.; Campbell, I. G.; Brown, M. A.; Dinger, M. E.; Mattick, J. S. (May 2011). "SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer". RNA. 17 (5): 878–891. doi:10.1261/rna.2528811. PMC 3078737. PMID 21460236.
- ↑ Huttenhofer, Alexander; Kiefmann, Martin; Meier-Ewert, Sebastian; O'Brien, John; Lehrach, Hans; Bachellerie, Jean-Pierre; Brosius, Jürgen (1 June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
- ↑ Kiss, Tamás (2002). "Small Nucleolar RNAs". Cell. 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.