Sialyl-Lewis A

Sialyl-Lewis A
Identifiers
92448-22-1
3D model (Jmol) Interactive image
MeSH sialyl+Lewis+A
Properties
C31H52N2O23
Molar mass 820.75 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Sialyl-LewisA, also known as sialyl LeA and SLeA, is a tetrasaccharide carbohydrate that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.

Occurrence of the Sialyl-Lewis A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.[1]

See also

References

  1. Matsui T, Kojima T, Suzuki H, Hamajima H, Nakazato H, Ito K, Nakao A, Sakamoto J (June 2004). "Sialyl Lewisa Expression as a Predictor of the Prognosis of Colon Carcinoma Patients in a Prospective Randomized Clinical Trial". Japanese Journal of Clinical Oncology. 34 (10): 588–593. doi:10.1093/jjco/hyh110.
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