Sclerotiorin

Sclerotiorin
Identifiers

3D model (Jmol)	Interactive image
ChemSpider	4940697
PubChem	6436015
InChI InChI=1S/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1 Key: SWJLTKXURNHVHE-UPWXJBBJSA-N InChI=1/C21H23ClO5/c1-6-12(2)9-13(3)7-8-15-10-16-17(11-26-15)19(24)21(5,27-14(4)23)20(25)18(16)22/h7-12H,6H2,1-5H3/b8-7+,13-9+/t12-,21+/m0/s1 Key: SWJLTKXURNHVHE-UPWXJBBJBP
SMILES CC[C@H](C)/C=C(\C)/C=C/C1=CC2=C(C(=O)[C@](C(=O)C2=CO1)(C)OC(=O)C)Cl
Properties
Chemical formula	C₂₁H₂₃ClO₅
Molar mass	390.86 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Sclerotiorin is an antimicrobial Penicillium frequentans isolate. Sclerotiorin is an aldose reductase inhibitor (IC₅₀=0.4 μM) as well as a reversible lipoxygenase inhibitor (IC₅₀=4.2 μM).^[1]^[2]

Notes

↑ Chidananda, C; Rao, LJ; Sattur, AP (2006). "Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase". Biotechnology letters. 28 (20): 1633–6. doi:10.1007/s10529-006-9133-4. PMID 16900332.
↑ Chidananda C, Sattur AP (2007). "Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans.". J Agric Food Chem. 55 (8): 2879–83. doi:10.1021/jf062032x. PMID 17385879.

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