SYNJ2

SYNJ2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SYNJ2, INPP5H, synaptojanin 2
External IDs MGI: 1201671 HomoloGene: 117703 GeneCards: SYNJ2
Orthologs
Species Human Mouse
Entrez

8871

20975

Ensembl

ENSG00000078269

ENSMUSG00000023805

UniProt

O15056

Q9D2G5

RefSeq (mRNA)

NM_001178088
NM_003898

NM_001113351
NM_001113352
NM_001113353
NM_001290698
NM_011523

RefSeq (protein)

NP_003889.1
NP_001171559.1

NP_001106822.1
NP_001106823.1
NP_001106824.1
NP_001277627.1
NP_035653.2

Location (UCSC) Chr 6: 157.98 – 158.1 Mb Chr 17: 5.94 – 6.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene. [3]

Function

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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