SNRPG

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR

Identifiers

Aliases

SNRPG, SMG, Sm-G, small nuclear ribonucleoprotein polypeptide G

External IDs

HomoloGene: 37730 GeneCards: SNRPG

Gene ontology
Molecular function	• protein binding • RNA binding • poly(A) RNA binding
Cellular component	• cytoplasm • small nucleolar ribonucleoprotein complex • SMN-Sm protein complex • cytosol • catalytic step 2 spliceosome • spliceosomal tri-snRNP complex • U5 snRNP • U12-type spliceosomal complex • intracellular ribonucleoprotein complex • U2 snRNP • nucleoplasm • U1 snRNP • methylosome • U7 snRNP • precatalytic spliceosome • small nuclear ribonucleoprotein complex • P granule • spliceosomal complex • U4 snRNP • U2-type prespliceosome • nucleus
Biological process	• mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • spliceosomal snRNP assembly • spliceosomal complex assembly • RNA splicing • histone mRNA metabolic process • nuclear import
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6637


n/a

Ensembl


ENSG00000143977


n/a

UniProt


P62308 Q49AN9


n/a

RefSeq (mRNA)

NM_003096 NM_001317165 NM_001317166 NM_001317167 NM_001317168
NM_001317169 NM_001317171


n/a

RefSeq (protein)


NP_003087.1 NP_001304097.1 NP_001304098.1


n/a

Location (UCSC)

Chr 2: 70.28 – 70.29 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.^[2]^[3]

Interactions

SNRPG has been shown to interact with DDX20^[4] and TACC1.^[5]

References

↑ "Human PubMed Reference:".
↑ Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (June 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". EMBO J. 14 (9): 2076–88. PMC 398308. PMID 7744013.
↑ "Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G".
↑ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
↑ Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (August 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Heinrichs V, Hackl W, Lührmann R (1992). "Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro". J. Mol. Biol. 227 (1): 15–28. doi:10.1016/0022-2836(92)90678-D. PMID 1387914.
Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Bühler D, Raker V, Lührmann R, Fischer U (1999). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

RNA-binding protein: Ribonucleoproteins

snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 C L R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

SNRPG

Interactions

References

Further reading