Retinoid receptor
Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis.[1]
Subtypes include:
References
- ↑ Dyall SC, Michael GJ, Michael-Titus AT (2010). "Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats". Journal of Neuroscience Research. 88 (10): 2091–2102. doi:10.1002/jnr.22390. PMID 20336774.
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(2) Zinc finger DNA-binding domains |
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| (2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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| subfamily 2 | |
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| subfamily 3 | |
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| subfamily 4 | |
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| subfamily 5 | |
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| subfamily 6 | |
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| subfamily 0 | |
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| (2.2) Other Cys4 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5) Alternating composition | |
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| (2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
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CAR | |
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ERR | | |
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| | Agonists |
- DY-131 (GSK-9089)
- GSK-4716 (GW-4716)
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| Antagonists | |
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FXR | |
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LXR | |
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PPAR | | |
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| | Agonists | |
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| SPPARMs | |
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| Antagonists |
- FH-535
- GW-9662
- SR-202
- T-0070907
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| Unknown | |
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| Unselective | |
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| Unsorted | |
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PXR | |
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RAR | Agonists | |
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| Antagonists |
- BMS-195614
- BMS-493
- CD-2665
- ER-50891
- LE-135
- MM-11253
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| Others |
- Retinoic acid metabolism inhibitors: Liarozole
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RXR | Agonists | |
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| Antagonists |
- HX-531
- HX-630
- LG-100754
- PA-452
- UVI-3003
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SHR | | See here instead. |
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TR | |
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