RARS (gene)

RARS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RARS, ArgRS, DALRD1, HLD9, arginyl-tRNA synthetase
External IDs MGI: 1914297 HomoloGene: 68281 GeneCards: RARS
Orthologs
Species Human Mouse
Entrez

5917

104458

Ensembl

ENSG00000113643

ENSMUSG00000018848

UniProt

P54136

Q9D0I9

RefSeq (mRNA)

NM_002887

NM_025936

RefSeq (protein)

NP_002878.2

NP_080212.2

Location (UCSC) Chr 5: 168.49 – 168.52 Mb Chr 11: 35.81 – 35.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene.[3][4]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.[4]

Genetics

Mutations in RARS cause hypomyelination .[5]

Interactions

RARS (gene) has been shown to interact with QARS.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Girjes AA, Hobson K, Chen P, Lavin MF (December 1995). "Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase". Gene. 164 (2): 347–50. doi:10.1016/0378-1119(95)00502-W. PMID 7590355.
  4. 1 2 "Entrez Gene: RARS arginyl-tRNA synthetase".
  5. Wolf, N. I.; Salomons, G. S.; Rodenburg, R. J.; Pouwels, P. J.; Schieving, J. H.; Derks, T. G.; Fock, J. M.; Rump, P; Van Beek, D. M.; Van Der Knaap, M. S.; Waisfisz, Q (2014). "Mutations in RARS cause hypomyelination". Annals of Neurology. 76 (1): 134–9. doi:10.1002/ana.24167. PMID 24777941.
  6. Kim, T; Park S G; Kim J E; Seol W; Ko Y G; Kim S (July 2000). "Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex". J. Biol. Chem. UNITED STATES. 275 (28): 21768–72. doi:10.1074/jbc.M002404200. ISSN 0021-9258. PMID 10801842.

Further reading


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