RARRES1

Identifiers

Aliases

RARRES1, LXNL, TIG1, PERG-1, retinoic acid receptor responder 1

External IDs

MGI: 1924461 HomoloGene: 2166 GeneCards: RARRES1

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5918


109222

Ensembl


ENSG00000118849


ENSMUSG00000049404

UniProt


P49788


n/a

RefSeq (mRNA)


NM_002888 NM_206963


NM_001164763

RefSeq (protein)


NP_002879.2 NP_996846.1


n/a

Location (UCSC)

Chr 3: 158.7 – 158.73 Mb

Chr 3: 67.48 – 67.52 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.^[3]^[4]^[5]

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA (May 1996). "Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin". J Invest Dermatol. 106 (2): 269–74. doi:10.1111/1523-1747.ep12340668. PMID 8601727.
↑ Duvic M, Nagpal S, Asano AT, Chandraratna RA (Sep 1997). "Molecular mechanisms of tazarotene action in psoriasis". J Am Acad Dermatol. 37 (2 Pt 3): S18–24. doi:10.1016/s0190-9622(97)80396-9. PMID 9270552.
1 2 "Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1".

Jing C, El-Ghany MA, Beesley C, et al. (2002). "Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity.". J. Natl. Cancer Inst. 94 (7): 482–90. doi:10.1093/jnci/94.7.482. PMID 11929948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang J, Liu L, Pfeifer GP (2004). "Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene.". Oncogene. 23 (12): 2241–9. doi:10.1038/sj.onc.1207328. PMID 14691453.
Youssef EM, Chen XQ, Higuchi E, et al. (2004). "Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers.". Cancer Res. 64 (7): 2411–7. doi:10.1158/0008-5472.CAN-03-0164. PMID 15059893.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mizuiri H, Yoshida K, Toge T, et al. (2005). "DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage.". Cancer Sci. 96 (9): 571–7. doi:10.1111/j.1349-7006.2005.00082.x. PMID 16128742.
Shutoh M, Oue N, Aung PP, et al. (2006). "DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.". Cancer. 104 (8): 1609–19. doi:10.1002/cncr.21392. PMID 16134180.

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RARRES1

References

Further reading