RAG1

Identifiers

RAG1, RAG-1, RNF74, recombination activating gene 1

External IDs

MGI: 97848 HomoloGene: 387 GeneCards: RAG1

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • protein homodimerization activity • ubiquitin protein ligase activity • histone binding • zinc ion binding • metal ion binding • ubiquitin-protein transferase activity • ligase activity • protein binding • catalytic activity • nucleic acid binding • nuclease activity • endonuclease activity • hydrolase activity
Cellular component	• nucleoplasm • nucleus
Biological process	• positive regulation of T cell differentiation • histone monoubiquitination • DNA recombination • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • adaptive immune response • T cell differentiation in thymus • nucleic acid phosphodiester bond hydrolysis • thymus development • negative regulation of thymocyte apoptotic process • T cell homeostasis • negative regulation of T cell apoptotic process • immune response • V(D)J recombination • pre-B cell allelic exclusion • B cell differentiation • metabolic process • regulation of T cell differentiation • protein autoubiquitination • covalent chromatin modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5896


19373

Ensembl


ENSG00000166349


ENSMUSG00000061311

UniProt


P15918


P15919

RefSeq (mRNA)


NM_000448


NM_009019

RefSeq (protein)


NP_000439.1


NP_033045.2

Location (UCSC)

Chr 11: 36.51 – 36.59 Mb

Chr 2: 101.64 – 101.65 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

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Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.^[3]

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.^[3]

References

This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.