Polyamine-modulated factor 1

PMF1

Identifiers

External IDs

Gene ontology
Molecular function	• transcription coactivator activity • leucine zipper domain binding • protein binding
Cellular component	• chromosome • condensed chromosome kinetochore • cytosol • MIS12/MIND type complex • chromosome, centromeric region • nucleus • kinetochore • transcription factor complex • nucleoplasm
Biological process	• chromosome segregation • cell division • cell cycle • regulation of transcription, DNA-templated • mitotic nuclear division • transcription from RNA polymerase II promoter • transcription, DNA-templated • sister chromatid cohesion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


11243


n/a

Ensembl


ENSG00000160783


n/a

UniProt


Q6P1K2


n/a

RefSeq (mRNA)


NM_007221 NM_001199653 NM_001199654


n/a

RefSeq (protein)


NP_001186582.1 NP_001186583.1 NP_001186590.1 NP_001186592.1 NP_009152.2


n/a

Location (UCSC)

Chr 1: 156.21 – 156.24 Mb

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.^[2]^[3]

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ Wang Y, Devereux W, Stewart TM, Casero RA Jr (Aug 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". J Biol Chem. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.
↑ "Entrez Gene: PMF1 polyamine-modulated factor 1".
↑ Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340.
↑ Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821.

Wang Y, Devereux W, Stewart TM, Casero RA (2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". Biochem. J. 355 (Pt 1): 45–9. doi:10.1042/0264-6021:3550045. PMC 1221710. PMID 11256947.
Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation". J. Cell Biol. 173 (1): 9–17. doi:10.1083/jcb.200509158. PMC 2063780. PMID 16585270.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

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Polyamine-modulated factor 1

Interactions

References

Further reading