Phthalyl amidase
phthalyl amidase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 3.5.1.79 | ||||||||
CAS number | 169150-79-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
|
In enzymology, a phthalyl amidase (EC 3.5.1.79) is an enzyme that catalyzes the chemical reaction
- a phthalylamide + H2O phthalic acid + a substituted amine
Thus, the two substrates of this enzyme are phthalylamide and H2O, whereas its two products are phthalic acid and substituted amine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is phthalyl-amide amidohydrolase.
References
- M (1996). "Discovery, purification, and properties of o-phthalyl amidase from Xanthobacter agilis". J. Mol. Catal., B Enzym. 2: 53–69. doi:10.1016/1381-1177(96)00011-2.
- Zmijewski MJ; Briggs, Barbara S.; Evans, Robert; Muth, William L.; Vangala, Surya; Zmijewski, Milton J. (1996). "o-Phthalyl amidase in the synthesis of Loracarbef: process development using this novel biocatalyst". Biotechnol. Lett. 18: 875–880. doi:10.1007/BF00154613.
- Costello C, Kreuzman A, Zmijewski M (1996). "Selective deprotection of phthalyl protected proteins". Tetrahedron Lett. 37: 7469–7472. doi:10.1016/0040-4039(96)01752-2.
- Briggs BS, Zmijewski MJ (1995). "Enzyme from microbial source: phthalyl amidase". Chem. Abstr. 123: 25010.
This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.