Phosphogluconate dehydratase
phosphogluconate dehydratase | |||||||||
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Identifiers | |||||||||
EC number | 4.2.1.12 | ||||||||
CAS number | 9024-33-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction
- 6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in Entner–Doudoroff pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.
References
- MELOCHE HP, WOOD WA (1964). "THE MECHANISM OF 6-PHOSPHOGLUCONIC DEHYDRASE". J. Biol. Chem. 239: 3505–10. PMID 14245409.