Philip S. Portoghese
Philip Salvatore Portoghese (born June 4, 1931) is an American chemist who has made notable contributions to the design and synthesis of ligands targeting opioid receptors. He is a Distinguished Professor of Medicinal Chemistry at the University of Minnesota, Twin Cities.[1] He has also served as the Editor-in-chief of the Journal of Medicinal Chemistry since 1972.[2]
Biography
Portoghese was born on June 4, 1931 in Brooklyn, New York. He received a B.S. in pharmacy and then went on to obtain an M.S. degree in physical pharmacy in 1958. He then continued at the University of Wisconsin–Madison and obtained a Ph.D in pharmaceutical chemistry under the mentorship of Dr.Edward E. Smissman in 1961. He joined the faculty of the Department of Medicinal Chemistry at University of Minnesota in 1961, where he has served with distinction for over five decades. He is known internationally for designing several opioid ligands including β-funaltrexamine,[3] naltrindole,[4] norbinaltorphimine,[5] and naltriben.[6] He has pioneered the use of bivalent ligands to target opioid receptor complexes called homomers and heteromers.[7][8][9][10] He was recently honored for 50 years of exemplary academic service by the University of Minnesota.[11] In 2007, he was inducted into the Hall of Fame of the American Chemical Society (ACS) Division of Medicinal Chemistry.[12] Dr. Portoghese served as Editor-in-chief of the Journal of Medicinal Chemistry from 1972 to 2012, making him one of the longest standing editors of an ACS journal.
Awards
Portoghese has been a recipient of numerous awards including:
- 1980 A.Ph.A./Academy of Pharmaceutical Sciences Research Achievement Award in Medicinal Chemistry
- 1984 American Association of Colleges of Pharmacy Ernest H. Volweiler Award for Outstanding Contributions to Research in the Pharmaceutical Sciences
- 1986 University of Catania honorary doctorate
- 1990 Division of Medicinal Chemistry, American Chemistry Society: Medicinal Chemistry Award
- 1990 Am. Assoc. of Pharmaceutical Scientists: Research Achievement Award in Medicinal Chemistry
- 1991 College on Problems of Drug Dependence, NAS-NRC: N.B. Eddy Award for Excellence in Drug Abuse Research
- 1991 Division of Medicinal Chemistry, Am. Chem. Soc.: E.E. Smissman-Bristol-Myers-Squibb Award
- 1992 Royal Danish School of Pharmacy, Copenhagen: Honorary Doctorate
- 1996 University of Wisconsin: Citation of Merit
- 1997-2006 National Institutes of Health: MERIT (Method to Extend Research In Time) Award
- 1999 Rho Chi Pharmacy Honor Society Award
- 1999 The Oak & the Tulip Medal, Società Chimica Italiana, and the European Federation for Medicinal Chemistry
- 2000 American Chemical Society: Alfred Burger Award in Medicinal Chemistry
- 2000 University of Minnesota: Distinguished Professor
- 2000 University of Minnesota: Citation of Excellence in Teaching, Research, and Service
- 2001 University of Minnesota: Weaver Medal, University of Minnesota, College of Pharmacy
- 2003 University of Minnesota: Academy for Excellence in Health Research, Academic Health Center
- 2006 European Federation of Medicinal Chemistry: Nauta Award in Pharmacochemistry
- 2007 Member, Medicinal Chemistry Hall of Fame, Div. of Medicinal Chemistry, Am. Chem. Society
References
- ↑ http://www.pharmacy.umn.edu/medchem/faculty/directory/faculty/portoghese/home.html
- ↑ http://pubs.acs.org/page/jmcmar/profile.html
- ↑ P.S. Portoghese, D.L. Larson, L.M. Sayre, D.S. Fries and A.E. Takemori, A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities, J. Med. Chem. 23 (1980), p. 233.
- ↑ Portoghese PS, Sultana M, Takemori AE. "Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist." European Journal of Pharmacology. 1988 Jan 27;146(1):185-6. doi:10.1016/0014-2999(88)90502-X PMID 2832195
- ↑ Portoghese PS, Lipkowski AW, Takemori AE. Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sciences. 1987 Mar 30;40(13):1287-92. PMID 2882399
- ↑ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
- ↑ Erez, M., Takemori, A. E. & Portoghese, P. S. (1982) J. Med. Chem. 25, 847–849.
- ↑ Bhushan, R. G., Sharma, S. K., Xie, Z., Daniels, D. J.&Portoghese, P. S. (2004), J. Med. Chem. 47, 2969–2972.
- ↑ Daniels, D.J., et al. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proceedings of the National Academy of Sciences 102(52):19208-19213, 2005. [Full Text]
- ↑ http://www.nida.nih.gov/NIDA_notes/NNvol22N1/Basic.html
- ↑ http://www.pharmacy.umn.edu/news/portoghesesymp/home.html
- ↑ http://www.acsmedchem.org/halloffame.html