Pentagastrin

Pentagastrin
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
ATC code V04CG04 (WHO)
Pharmacokinetic data
Biological half-life 10 minutes or less
Identifiers
CAS Number 5534-95-2 YesY
PubChem (CID) 9853654
IUPHAR/BPS 870
DrugBank DB00183 YesY
ChemSpider 8029364 YesY
UNII EF0NX91490 YesY
KEGG D01631 YesY
ChEMBL CHEMBL1328 YesY
ECHA InfoCard 100.024.445
Chemical and physical data
Formula C37H49N7O9S
Molar mass 767.893 g/mol
3D model (Jmol) Interactive image
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Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally.[2] It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.[3]

Pentagastrin's IUPAC chemical name is "N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide".

Pentagastrin stimulation test

Pentagastrin is also used as a stimulation test to elevate of several hormones, such as serotonin. It provokes flushing and is useful in evaluating patients who describe flushing, but have normal or only marginally elevated biochemical markers for carcinoid syndrome.

It has been used to stimulate ectopic gastric mucosa for the detection of Meckels diverticulum by nuclear medicine.

It is used to stimulate calcitonin release from residual parafollicular cell C-cells after total thyroidectomy for medullary thyroid carcinoma.

See also

References

  1. ↑ Martindale (1993). The extra pharmacopoeia (30th ed.). London: Pharmaceutical Press. ISBN 978-0853693000.
  2. ↑ Braganza, J. M.; Herman, K; Hine, P; Kay, G (1979). "The effect of pentagastrin on peptic secretion in man". The Journal of Physiology. 289: 9–16. doi:10.1113/jphysiol.1979.sp012721. PMC 1281354Freely accessible. PMID 379305.
  3. ↑ van Megen, HJ; Westenberg, HG; den Boer, JA; Haigh, JR; Traub, M (April 1994). "Pentagastrin induced panic attacks: enhanced sensitivity in panic disorder patients.". Psychopharmacology. 114 (3): 449–55. doi:10.1007/bf02249335. PMID 7855203.


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