Paul Sigler
Paul B. Sigler (February 19, 1934 – January 11, 2000[1][2]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.[4][8] Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim[3] and Helen Hay Whitney Fellowships.[7] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.[2]
Biography
Prior to coming to Yale, he was a professor at the University of Chicago.[3] He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955.[3] After briefly practicing medicine and working as a researcher for the NIH,[7] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology[3] working under David M. Blow[5] before moving to the University of Chicago.[3]
Memorials
A memorial plaque is located in front of the Bass Center for Structural Bilogy on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry.[9] Yale also has sponsored Paul Sigler memorial symposia in the past.[10] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.[11] He is buried at Coop Prairie Cemetery in Mansfield, Arkansas.[1]
Selected Publications
- Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311. doi:10.1038/379311a0. PMID 8552184.
- Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497. doi:10.1038/352497a0. PMID 1865905.
- Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578. doi:10.1038/371578a0. PMID 7935790.
- Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "Crystal structure of a yeast TBP/TATA-box complex". Nature. 365 (6446): 512. doi:10.1038/365512a0. PMID 8413604.
- Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911. doi:10.1126/science.2683088. PMID 2683088.
- Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. doi:10.1038/335321a0. PMID 3419502.
See also
References
- 1 2 3 4 5 6 Paul B. Sigler at Find a Grave
- 1 2 3 4 5 "(IUCr) Paul B. Sigler (1934-2000)".
- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 "New York Times Obit".
- 1 2 3 4 "Yale University Press Release".
- 1 2 "Blow on AcademicTree.org".
- ↑ "Paul B. Sigler, MD, PhD - HHMI.org". HHMI.org.
- 1 2 3 "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
- ↑ "Official Site".
- ↑ Paul Sigler Memorial
- ↑ "Paul Sigler Symposium".
- ↑ "Helen Hay Whitney Foundation - Announcement".
Further reading
- "New York Times Obit".
- "Yale obit".
- "(IUCr) Paul B. Sigler (1934-2000)".
- "Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology".
- Brian W. Matthews (2000). "Obituary: Paul Sigler (1934–2000)". Nature. 403 (6772): 848. doi:10.1038/35002722.
- Henderson, Richard (2000). "Paul Sigler: A structural biologist with passion". Nature Structure Biology. 7 (4): 271. doi:10.1038/74024.
- Jeruzalmi, David; Kuriyan, John; Doudna, Jennifer (2000). "Paul Sigler (1934–2000)". Trends in Biomedical Sciences. 25 (5): 221. doi:10.1016/S0968-0004(00)01587-5.
- Horwich, A; Joachimiak, A (2000). "Paul Sigler (1934–2000)". Protein Science. 9 (4): 827–828. PMC 2144625.
- Perutz, Max (2000). "Paul Sigler (1934–2000)". Cell. 101 (1): 23–4. doi:10.1016/S0092-8674(02)71111-2. PMID 10778852.
- Davies, David R (2000). "Obituary: Paul Sigler". Structure. 8 (3): R67–8. doi:10.1016/S0969-2126(00)00113-1. PMID 10745016.