PRKAB2

PRKAB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PRKAB2
External IDs MGI: 1336185 HomoloGene: 38046 GeneCards: PRKAB2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5565

108097

Ensembl

ENSG00000131791

ENSMUSG00000038205

UniProt

O43741

Q6PAM0

RefSeq (mRNA)

NM_005399

NM_182997

RefSeq (protein)

NP_005390.1

NP_892042.2

Location (UCSC) Chr 1: 147.16 – 147.17 Mb Chr 3: 97.66 – 97.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.[3][4]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.[4]

Interactions

PRKAB2 has been shown to interact with PRKAG2[5] and PRKAG1.[5]

Research on the genes CHD1L and PRKAB2 within lymphoblast cells[6] lead to the conclusion that anomalies appear with the 1q21.1-deletionsyndrome:

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (February 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
  4. 1 2 "Entrez Gene: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit".
  5. 1 2 Cheung, P C; Salt I P; Davies S P; Hardie D G; Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. ENGLAND. 346 (3): 659–69. doi:10.1042/0264-6021:3460659. ISSN 0264-6021. PMC 1220898Freely accessible. PMID 10698692.
  6. Harvard C, Strong E, Mercier E, Colnaghi R, Alcantara D, Chow E, Martell S, Tyson C, Hrynchak M, McGillivray B, Hamilton S, Marles S, Mhanni A, Dawson AJ, Pavlidis P, Qiao Y, Holden JJ, Lewis SM, O'Driscoll M, Rajcan-Separovic E (2011). "Understanding the impact of 1q21.1 copy number variant". Orphanet J Rare Dis. 6: 54. doi:10.1186/1750-1172-6-54. PMC 3180300Freely accessible. PMID 21824431.

Further reading


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