PRE-084

PRE-084
Clinical data

ATC code	none
Identifiers
IUPAC name 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
CAS Number	138847-85-5^Y
PubChem (CID)	126402
IUPHAR/BPS	6678
ChemSpider	112335^N
Chemical and physical data
Formula	C₁₉H₂₇NO₃
Molar mass	317.422 g/mol
3D model (Jmol)	Interactive image
SMILES c1ccccc1C2(CCCCC2)C(=O)OCCN3CCOCC3
InChI InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2^N Key:RQHKZUBCUZVZEF-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

PRE-084 is a sigma receptor agonist, selective for the σ₁ subtype. It has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects.^[1]^[2]^[3]^[4]^[5] PRE-084 increases the expression of GDNF.^[6]

References

↑ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994). "PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice". Pharmacology, Biochemistry, and Behavior. 49 (4): 859–69. doi:10.1016/0091-3057(94)90235-6. PMID 7886099.
↑ Maurice T (November 2001). "Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats". European Journal of Pharmacology. 431 (2): 223–7. doi:10.1016/S0014-2999(01)01436-4. PMID 11728429.
↑ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004). "Antitussive activity of sigma-1 receptor agonists in the guinea-pig". British Journal of Pharmacology. 141 (2): 233–40. doi:10.1038/sj.bjp.0705605. PMC 1574192. PMID 14691051.
↑ Skuza G, Rogóz Z (2009). "Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice". Pharmacological Reports : PR. 61 (6): 1179–83. PMID 20081254.
↑ Hiranita T, Soto PL, Tanda G, Katz JL (February 2010). "Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine". The Journal of Pharmacology and Experimental Therapeutics. 332 (2): 515–24. doi:10.1124/jpet.109.159236. PMC 2812106. PMID 19892920.
↑ Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X (May 2011). "Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury". J. Neurotrauma. 28 (5): 831–40. doi:10.1089/neu.2010.1674. PMID 21332255.

Sigma receptor modulators

Agonists	3-MeO-PCE 3-MeO-PCP 3-PPP 4-MeO-PCP 4-IBP 4-PPBP Afobazole Alazocine Amantadine Amitriptyline Arketamine BD-1008 BD1031 BD1052 Berberine Buprenorphine Captodiame Citalopram Clorgiline Cocaine Cutamesine Cyclazocine DHEA DHEA-S Desipramine Dextrallorphan Dextromethorphan Dextrorphan Dimemorfan DMT Donepezil DTG Escitalopram Fluoxetine Fluvoxamine Heroin Ibogaine Igmesine Imipramine JO-1784 Ketamine L-687,384 Lamotrigine Lu 28-179 MDMA Memantine Metaphit Methamphetamine Methoxetamine Methylphenidate Morphine Naluzotan Noscapine OPC-14523 Opipramol PB-28 PD-144,415 Pentazocine Pentoxyverine Phencyclidine PRE-084 Pregnenolone Pregnenolone sulfate Quetiapine RTI-55 SA-4503 Siramesine Tapentadol Tenocyclidine Tramadol UMB23 UMB82 Venlafaxine

Antagonists	AC927 AHD1 AZ66 BD1008 BD1047 BD1060 BD1063 BD1067 BMY-14802 CM156 E-5842 Haloperidol Lamotrigine LR132 LR172 MIN-101 MS-377 Naloxone Naltrexone NE-100 Panamesine PD-144418 Progesterone Quingestrone Rimcazole S1RA (E-52862) Sertraline SM-21 SR-31742A UMB100 UMB101 UMB103 UMB116 YZ-011 YZ-069 YZ-185

Unknown / unsorted	4C-T-2 5-MeO-DiPT 18-MC β-Endopsychosin Chlorpromazine Clemastine Clocapramine Cloperastine D-Deprenyl DiPT DPT Gevotroline Nepinalone Selegiline TMA; Allosteric modulators: SKF-83959

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