PPAN

PPAN
Identifiers
Aliases PPAN, BXDC3, SSF, SSF-1, SSF1, SSF2, peter pan homolog (Drosophila)
External IDs MGI: 2178445 HomoloGene: 5690 GeneCards: PPAN
Orthologs
Species Human Mouse
Entrez

56342

235036

Ensembl

ENSG00000130810

ENSMUSG00000004100

UniProt

Q9NQ55

Q91YU8

RefSeq (mRNA)

NM_020230

NM_145610

RefSeq (protein)

NP_001035754.1
NP_064615.3

NP_663585.2

Location (UCSC) Chr 19: 10.11 – 10.11 Mb Chr 9: 20.89 – 20.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Suppressor of SWI4 1 homolog is a protein that in humans is encoded by the PPAN gene.[3][4]

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (PPAN). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and PPAN are essential for cell growth and proliferation. This gene was found to cotranscript with P2RY11/P2Y(11), an immediate downstream gene on the chromosome that encodes an ATP receptor. The chimeric transcripts of this gene and P2RY11 were found to be ubiquitously present and regulated during granulocytic differentiation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells.[4]

One of the introns of PPAN encodes the Small nucleolar RNA SNORD105.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Welch PJ, Marcusson EG, Li QX, Beger C, Kruger M, Zhou C, Leavitt M, Wong-Staal F, Barber JR (Sep 2000). "Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes". Genomics. 66 (3): 274–83. doi:10.1006/geno.2000.6230. PMID 10873382.
  4. 1 2 "Entrez Gene: PPAN peter pan homolog (Drosophila)".
  5. Vitali, P; Royo H; Seitz H; Bachellerie JP; Huttenhofer A; Cavaille J (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res. 31 (22): 65436551. doi:10.1093/nar/gkg849. PMC 275545Freely accessible. PMID 14602913.

Further reading


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