PJA1

PJA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L0B

Identifiers

PJA1, PRAJA1, RNF70, praja ring finger ubiquitin ligase 1

External IDs

MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1

Gene ontology
Molecular function	• zinc ion binding • ligase activity • protein binding • metal ion binding • ubiquitin protein ligase activity
Cellular component	• cytoplasm
Biological process	• protein catabolic process • protein ubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


64219


18744


ENSG00000181191


ENSMUSG00000034403


Q8NG27


O55176

RefSeq (mRNA)


NM_001032396 NM_022368 NM_145119


NM_001083110 NM_001290555 NM_001290556 NM_008853

RefSeq (protein)


NP_001027568.1 NP_071763.2 NP_660095.1


NP_001076579.1 NP_032879.2

Location (UCSC)

Chr X: 69.16 – 69.17 Mb

Chr X: 99.47 – 99.47 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.^[3]^[4]

Interactions

PJA1 has been shown to interact with UBE2D2^[3] and MAGED1.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Yu P, Chen Y, Tagle DA, Cai T (May 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
↑ "Entrez Gene: PJA1 praja 1".
↑ Sasaki, Aya; Masuda Yoshiko; Iwai Kazuhiro; Ikeda Kyoji; Watanabe Ken (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. United States. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. ISSN 0021-9258. PMID 11959851.

Further reading

Mishra L, Tully RE, Monga SP, et al. (1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
Fang S, Jensen JP, Ludwig RL, et al. (2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". J. Biol. Chem. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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