Odorant-binding protein

Pheromone/general odorant-binding protein

Identifiers

Symbol

PBP_GOBP

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

odorant-binding protein 2A

Identifiers
Symbol	OBP2A
Alt. symbols	hOBPIIa, OBP
Entrez	29991
HUGO	23380
OMIM	164320
RefSeq	NM_014582
UniProt	Q9NY56
Other data
Locus	Chr. 9 q34

odorant-binding protein 2B
Identifiers
Symbol	OBP2B
Alt. symbols	hOBPIIb
Entrez	29989
HUGO	23381
OMIM	604606
RefSeq	NM_014581
UniProt	Q9NPH6
Other data
Locus	Chr. 9 q34

Odorant-binding proteins are abundant small soluble proteins secreted in the nasal mucus of many animal species and in the sensillar lymph of chemosensory sensilla of insects.

The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant-binding proteins, which exist in the extracellular fluid surrounding the odorant receptors.^[1] This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant-binding proteins (GOBP).

These proteins were initially identified on the basis of their ability to bind with moderate-affinity radioactively labeled odorants.^[2]^[3]

References

↑ Prestwich GD, Vogt RG, Lerner MR (1991). "Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects". J. Neurobiol. 22 (1): 74–84. doi:10.1002/neu.480220108. PMID 2010751.
↑ Pelosi P, Baldaccini NE, Pisanelli AM (January 1982). "Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine". Biochem. J. 201 (1): 245–8. PMC 1163633. PMID 7082286.
↑ PDB ID: 1CI0 W. Shi, D.A. Ostrov, S.E. Gerchman, V. Graziano, H. Kycia, B. Studier, S.C. Almo, S.K. Burley, New York Structural GenomiX Research Consortium (NYSGXRC). The Structure of PNP Oxidase from S. cerevisiae

Proteins: carrier proteins

Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7

Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin

Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor

Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin

Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin

Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

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