Network of Cancer Genes

Network of Cancer Genes
Content
Description A web resource on systems-level properties of cancer genes
Contact
Research center King's College London
Primary citation PMID 26516186
Release date October 2015
Access
Website http://ncg.kcl.ac.uk
Miscellaneous
Version 5.0[1]

Network of Cancer Genes is a web resource on systems-level properties of cancer genes and oncomiRs.

NCG reports information on duplicability, orthology, evolutionary appearance, interactions, function, expression of a manually curated list of 1,571 protein-coding cancer genes.[2] Cancer genes are genes with a driver role in the onset of human cancer upon mutations of their sequence[3] and/or amplifications of their genomic locus.[4] The list of cancer genes is derived from the union of the Cancer Gene Census (known cancer genes) and from the results of 77 whole genome or whole exome cancer-resequencing screenings (candidate cancer genes). In addition, the database also annotates possible false positives, defined as candidate cancer genes whose association with cancer is likely to be spurious.[5] NCG is also available as a smart phone application for Android.

Cancer Types

NCG currently stores information on the following 23 cancer types:

Old Versions

See also

References

  1. ↑ An, Omer; Giovanni M. Dall'Olio; Thanos P. Mourikis; Ciccarelli, Francesca D. (2015). "NNCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings". Nucl. Acids Res. 2015: D992–9. doi:10.1093/nar/gkv1123. PMC 4702816Freely accessible. PMID 26516186.
  2. ↑ An, Omer; Pendino, Vera; D’Antonio, Matteo; Ratti, Emanuele; Gentilini, Marco; Ciccarelli, Francesca D. (2014). "NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes". Database. 2014: bau015. doi:10.1093/database/bau015. PMC 3948431Freely accessible. PMID 24608173. Cite uses deprecated parameter |coauthors= (help)
  3. ↑ Futreal, P. Andrew (March 2004). "A census of human cancer genes". Nature Reviews Cancer. 4 (3): 177–183. doi:10.1038/nrc1299. PMC 2665285Freely accessible. PMID 14993899.
  4. ↑ Santarius, Thomas (January 2010). "A census of amplified and overexpressed human cancer genes". Nature Reviews Cancer. 10 (1): 59–64. doi:10.1038/nrc2771. PMID 20029424.
  5. ↑ Lawrence, Michael S. (11 July 2013). "Mutational heterogeneity in cancer and the search for new cancer-associated genes". Nature. 499 (7457): 214–218. doi:10.1038/nature12213. PMC 3919509Freely accessible. PMID 23770567.
  6. ↑ D'Antonio, Matteo; Pendino, Vera; Sinha, Shruti; Ciccarelli, Francesca D. (2012). "Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes". Nucl. Acids Res. 40 (Database issue): D978–83. doi:10.1093/nar/gkr952. PMC 3245144Freely accessible. PMID 22080562.
  7. ↑ Syed, Adnan S.; D'Antonio, Matteo; Ciccarelli, Francesca D. (2010). "Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes". Nucl. Acids Res. 38 (Database issue): D670–5. doi:10.1093/nar/gkp957. PMC 2808873Freely accessible. PMID 19906700.
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