Nanoelectromechanical systems mass spectrometer

A nanoelectromechanical systems mass spectrometer (NEMS MS) is an instrument measuring the mass of analyte particles by detecting the frequency shift caused by the adsorption of the particles on a NEMS resonator.

It was first reported by a group of scientists led by Michael Roukes at the California Institute of Technology in 2004.[1] They developed single molecule analysis in 2009.[2] [3] Single-biomolecule mass measurements were accomplished in 2012.[4] A hybrid NEMS-MS/TOF-MS instrument was reported in 2015.[5]

See also

References

  1. ↑ Ekinci, K. L.; Huang, X. M. H.; Roukes, M. L. (2004). "Ultrasensitive nanoelectromechanical mass detection". Applied Physics Letters. 84 (22): 4469. doi:10.1063/1.1755417.
  2. ↑ Naik, A. K.; Hanay, M. S.; Hiebert, W. K.; Feng, X. L.; Roukes, M. L. (21 June 2009). "Towards single-molecule nanomechanical mass spectrometry". Nature Nanotechnology. 4 (7): 445–450. doi:10.1038/nnano.2009.152.
  3. ↑ US application 2009/0261241, Roukes et al, "Single molecule mass spectroscopy enabled by nanoelectromechanical systems (nems-ms)", published 2009-10-22
  4. ↑ Hanay, M. S.; Kelber, S. K.; Naik, A. K.; Chi, D.; Hentz, S.; Bullard, E.C.; Colinet, E.; Duraffourg, L.; Roukes, M.L. (26 August 2012). "Single-protein nanomechanical mass spectrometry in real time". Nature Nanotechnology. 7 (9): 602–608. doi:10.1038/NNANO.2012.119.
  5. ↑ Sage, Eric; Brenac, Ariel; Alava, Thomas; Morel, Robert; Dupré, Cécilia; Hanay, Mehmet Selim; Roukes, Michael L.; Duraffourg, Laurent; Masselon, Christophe; Hentz, Sébastien (10 March 2015). "Neutral particle mass spectrometry with nanomechanical systems". Nature Communications. 6: 6482. doi:10.1038/ncomms7482.
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