Mitosene

Not to be confused with mitosan.

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.[1][2]

References

  1. ↑ Maliepaard, Marc; de Mol, Nico J.; Tomasz, Maria; Gargiulo, Dario; Janssen, Lambert H. M.; van Duynhoven, John P. M.; van Velzen, Ewoud J. J.; Verboom, Willem; Reinhoudt, David N. (1997). "Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation". Biochemistry. 36 (30): 9211–9220. doi:10.1021/bi9700680.
  2. ↑ Iyengar, 1 Bhashyam S.; Remers, William A. (1985). "A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes". J. Med. Chem. 28 (7): 963–967. doi:10.1021/jm00145a021.
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