Macroglobulin

IgM, pictured, is an example of a macroglobulin. Another example is alpha-2 macroglobulin.

A macroglobulin is a plasma globulin of high molecular weight.^[1]

Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood vessels when temperature drops (as in cryoglobulinaemia).

Other macroglobulins include alpha-2 macroglobulin, which is elevated in nephrotic syndrome, diabetes, severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease.

References

Macroglobulins at the US National Library of Medicine Medical Subject Headings (MeSH)

serpins:	alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin) alpha-2 (Alpha 2-antiplasmin) Antithrombin (Heparin cofactor II)

carrier proteins:	alpha-1 (Transcortin) alpha-2 (Ceruloplasmin) Retinol binding protein

other:	alpha-1 (Orosomucoid) alpha-2 (alpha-2-Macroglobulin, Haptoglobin)

carrier proteins:	Sex hormone-binding globulin Transferrin

other:	Angiostatin Hemopexin Beta-2 microglobulin Factor H Plasminogen Properdin

Other

Other globulins

Egg white	Conalbumin Ovalbumin Avidin

Serum albumin	Human serum albumin Bovine serum albumin Prealbumin

Other	C-reactive protein Lactalbumin (Alpha-lactalbumin) Parvalbumin Ricin

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