MYL6B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1OE9, 1W7I, 1W7J

Identifiers

Aliases

MYL6B, MLC1SA, myosin light chain 6B

External IDs

MGI: 1917789 HomoloGene: 86887 GeneCards: MYL6B

Gene ontology
Molecular function	• calcium ion binding • structural constituent of muscle • motor activity • protein binding
Cellular component	• cytosol • muscle myosin complex • unconventional myosin complex • extracellular exosome • myosin complex
Biological process	• muscle contraction • skeletal muscle tissue development • muscle filament sliding
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


140465


216459

Ensembl


ENSG00000196465


ENSMUSG00000039824

UniProt


P14649


Q8CI43

RefSeq (mRNA)


NM_002475 NM_001199629


NM_172259

RefSeq (protein)


NP_001186558.1 NP_002466.1


NP_758463.1

Location (UCSC)

Chr 12: 56.15 – 56.16 Mb

Chr 10: 128.49 – 128.5 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.^[3]^[4]^[5]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res. 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161.
↑ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. PMC 360973. PMID 2304459.
1 2 "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle".

Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell. Sci. 109 (8): 2089–99. PMID 8856505.
Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.

PDB gallery

1oe9: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN - NUCLEOTIDE-FREE 1w7i: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITHOUT NUCLEOTIDE SOAKED IN 10 MM MGADP 1w7j: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR

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MYL6B

References

Further reading