Losoxantrone

Losoxantrone
Identifiers
CAS Number 88303-60-0 YesY
PubChem (CID) 72116
ChemSpider 65094 YesY
Chemical and physical data
Formula C22H27N5O4
Molar mass 425.48088 g/mol
3D model (Jmol) Interactive image

Losoxantrone (biantrazole) is a anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone.[1][2] It is also sometimes known as DuP 941.[3]

See also

References

  1. Showalter, H. D. H.; Johnson, J. L.; Hoftiezer, J. M.; Turner, W. R.; Werbel, L. M.; Leopold, W. R.; Shillis, J. L.; Jackson, R. C.; Elslager, E. F. (1987). "Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias". Journal of Medicinal Chemistry. 30: 121. doi:10.1021/jm00384a021.
  2. Beylin, V. G.; Colbry, N. L.; Goel, O. P.; Haky, J. E.; Johnson, D. R.; Johnson, J. L.; Kanter, G. D.; Leeds, R. L.; Leja, B.; Lewis, E. P.; Rithner, C. D.; Showalter, H. D. H.; Sercel, A. D.; Turner, W. R.; Uhlendorf, S. E. (1989). "Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride". Journal of Heterocyclic Chemistry. 26: 85. doi:10.1002/jhet.5570260117.
  3. Leteurtre, F.; Kohlhagen, G.; Paull, K. D.; Pommier, Y. (17 August 1994). "Topoisomerase II Inhibition and Cytotoxicity of the Anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute Preclinical Antitumor Drug Discovery Screen". JNCI Journal of the National Cancer Institute. 86 (16): 1239–1244. doi:10.1093/jnci/86.16.1239.
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