List of adverse effects of sertraline
Adverse effects of sertraline by incidence.[1][2][3][4]
Very common (>10%)
Common (1-10%)
- Agitation
- Anorexia
- Constipation
- Dyspepsia (indigestion)
- Decreased libido
- Sweating
- Tremor
- Vomiting
- Impaired concentration
- Nervousness
- Paroniria (i.e., depraved or morbid dreaming/nightmares)
- Yawning
- Palpitations
- Increased sweating
- Hot flushes
- Weight decrease
- Weight increase
- Myoclonus
- Hypertonia
- Bruxism (teeth grinding)
- Hypoaesthesia
- Menstrual irregularities
- Sexual dysfunction
- Rash
- Vision abnormal
- Asthenia
- Chest pain
- Paraesthesia
- Tinnitus (hearing ringing in the ears)
Uncommon (0.1-1%)
- Hypertension (high blood pressure)
- Hyperkinesia
- Bronchospasm
- Oesophagitis (swollen oesophagus)
- Dysphagia
- Haemorrhoids
- Periorbital Oedema
- Purpura
- Cold Sweat
- Dry skin
- Nocturia
- Urinary Retention
- Polyuria (excessive urination)
- Vaginal Haemorrhage
- Malaise
- Chills
- Pyrexia (fever)
- Thirst
- Pollakiuria
- Micturition disorder
- Salivary Hypersecretion
- Tongue Disorder
- Osteoarthritis
- Muscular Weakness
- Back Pain
- Muscle Twitching
- Eructation (belching)
- Dyspnoea (air hunger)
- Epistaxis (nose bleed)
- Oedema peripheral
- Periorbital edema
- Syncope
- Postural dizziness
- Tachycardia (high heart rate)
- Urticaria (hives)
- Migraine
- Abnormal bleeding (esp. in the GI tract)
- Muscle cramps
- Arthralgia
- Depressive symptoms
- Euphoria
- Hallucination
- Alopecia (hair loss)
- Urinary Retention (being unable to pass urine)
- Pruritus
- Amnesia memory loss.
- Urinary incontinence
- Eye pain
- Asymptomatic elevations in serum transaminases
- Abnormal semen
- Melaena (black faeces due to a bleed in the stomach)
- Coffee ground vomiting
- Haematochezia
- Stomatitis (swollen mouth)
- Tongue ulceration
- Tooth Disorder
- Glossitis (soreness/swelling of the tongue)
- Mouth Ulceration
- Laryngospasm
- Hyperventilation (breathing more often than required to keep one's blood sufficiently oxygenated)
- Hypoventilation (breathing less often than required to keep one's blood sufficiently oxygenated)
- Stridor
- Dysphonia (voice disorder)
- Upper Respiratory Tract Infection
- Rhinitis (irritation/inflammation inside the nose)
- Hiccups
- Apathy
- Thinking Abnormal
Rare (<0.1%)
- Allergic reaction
- Allergy
- Anaphylactoid reaction
- Face oedema
- Priapism
- Atrial arrhythmia
- AV block
- Coma
- Peripheral Ischaemia
- Injury
- Vasodilation Procedure
- Lymphadenopathy
- Involuntary muscle contractions
- Galactorrhoea (lactation that is unrelated to pregnancy or breastfeeding)
- Gynaecomastia (swelling of breast tissue in men)
- Hyperprolactinaemia (high blood prolactin levels)
- Hypothyroidism (underactive thyroid gland)
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
- Pancreatitis (swollen pancreas)
- Altered platelet function
- Haematuria (blood in the urine)
- Leukopenia (low white blood cell count)
- Thrombocytopenia (low blood platelet count)
- Increased coagulation times
- Abnormal clinical laboratory results
- Hyponatraemia (low blood sodium)
- Conversion Disorder
- Drug Dependence
- Paranoia
- Myocardial Infarction (heart attack)
- Bradycardia
- Cardiac Disorder
- Suicidal Ideation/behaviour
- Sleep Walking
- Premature Ejaculation
- Hyperglycemia (high blood sugar)
- Hypoglycemia (low blood sugar)
- Hypercholesterolaemia (high blood cholesterol)
- Vasculitis
- Aggressive reaction
- Psychosis (hallucinations and delusions)
- Mania (a dangerously elated mood)
- Menorrhagia (an abnormally excessive amount of menstrual bleeding)
- Atrophic Vulvovaginitis
- Balanoposthitis
- Genital Discharge
- Angioedema
- Photosensitivity skin reaction
- Enuresis
- Visual field defect
- Abnormal liver function
- Dermatitis
- Dermatitis Bullous
- Rash Follicular
- Glaucoma
- Lacrimal Disorder
- Scotoma
- Diplopia
- Photophobia
- Hyphaema
- Mydriasis
- Hair Texture Abnormal
- Neoplasm
- Diverticulitis
- Choreoathetosis
- Dyskinesia
- Hyperaesthesia
- Sensory Disturbance
- Gastroenteritis
- Otitis Media
- Skin Odour Abnormal
Unknown frequency
- QTc prolongation
- Anaphylactoid Reaction
- Allergic Reaction
- Allergy
- Neuroleptic malignant syndrome. A potentially fatal reaction that most often occurs as a result of the use of antipsychotic drugs. It is characterised by fever, muscle rigidity, rhabdomyolysis (muscle breakdown), profuse sweating, tachycardia, tachypnoea (rapid breathing), agitation.
- Stevens-Johnson syndrome a potentially fatal skin reaction.
- Toxic epidermal necrolysis another potentially fatal skin reaction.
- Torsades de pointes a potentially fatal change in the heart's rhythm.
- Cerebrovascular spasm
- Serotonin syndrome similar to neuroleptic malignant syndrome but develops more rapidly (over a period of hours instead of days/weeks for neuroleptic malignant syndrome)
- Bone fracture
- Movement disorders
- Diabetes mellitus
- Dyspnoea
- Jaundice yellowing of the skin, mucous membranes and eyes due to an impaired ability of the liver to clear the haem breakdown by product, bilirubin.
- Hepatitis
- Liver failure
References
- ↑ "Zoloft (sertraline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 30 September 2013.
- ↑ "PRODUCT INFORMATION ZOLOFT® (sertraline hydrochloride)" (PDF). TGA eBusiness Services. Pfizer Australia Pty Ltd. 28 May 2013. Retrieved 30 September 2013.
- ↑ "Sertraline 100mg Film coated Tablets - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Accord Healthcare Limited. 25 August 2013. Retrieved 27 November 2013.
- ↑ "ZOLOFT (sertraline hydrochloride) tablet, film coated [PD-Rx Pharmaceuticals, Inc.]". DailyMed. PD-Rx Pharmaceuticals, Inc. September 2011. Retrieved 27 November 2013.
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