| Title | Director | Cast | Genre | Notes |
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| The Abandoned | Nacho Cerdà | Anastasia Hille, Karel Roden | Horror | Co-production with Spain | |
| Alien Autopsy | Jonny Campbell | Ant & Dec, Jimmy Carr | Comedy | |
| Amazing Grace | Michael Apted | Ioan Gruffudd, Albert Finney | Biopic | |
| Antonio's Breakfast | Daniel Mulloy | George Irving | Short | Academy Award Best Short |
| As You Like It | Kenneth Branagh | Romola Garai, Alfred Molina | Comedy | |
| Basic Instinct 2 | Michael Caton-Jones | Sharon Stone, David Morrissey | Thriller | |
| Breaking and Entering | Anthony Minghella | Jude Law, Juliette Binoche | Romantic drama | |
| Cashback | Sean Ellis | Sean Biggerstaff, Emilia Fox | Drama | |
| Casino Royale | Martin Campbell | Daniel Craig, Eva Green, Mads Mikkelsen | Spy/Action | Reboot of the James Bond franchise. |
| Children of Men | Alfonso Cuarón | Julianne Moore, Clive Owen | Sci-fi | |
| A Cock and Bull Story | Michael Winterbottom | Steve Coogan, Rob Brydon, Keeley Hawes | Comedy | |
| Colour Me Kubrick | Michael Fitzgerald | John Malkovich, Richard E. Grant | Comedy | |
| Confetti | Debbie Isitt | Martin Freeman, Jessica Stevenson | Mockumentary | |
| Driving Lessons | Jeremy Brock | Julie Walters, Rupert Grint, Laura Linney | Comedy/drama | Entered into the 28th Moscow International Film Festival |
| The Flying Scotsman | Douglas Mackinnon | Jonny Lee Miller, Laura Fraser | Sports | |
| A Good Year | Ridley Scott | Russell Crowe | Romantic comedy | based on A Good Year by Peter Mayle |
| Half Light | Craig Rosenberg | Demi Moore, Hans Matheson | Thriller | |
| The History Boys | Nicholas Hytner | Richard Griffiths, Domonic Cooper | Drama | |
| The Kovak Box | Daniel Monzón | Timothy Hutton, Lucía Jiménez | Thriller | Co-production with Spain |
| The Last King of Scotland | Kevin Macdonald | Forest Whitaker, James McAvoy | drama | Won Academy Award for Best Actor |
| London to Brighton | Paul Andrew Williams | Lorraine Stanley, Georgia Groome | Crime/Drama | |
| Love and Other Disasters | Alek Keshishian | Brittany Murphy, Matthew Rhys, Catherine Tate | Comedy/Romance | Co-production with France |
| Notes on a Scandal | Richard Eyre | Judi Dench, Cate Blanchett | Drama | |
| Peter and the Wolf | Suzie Templeton | | Animated Short | Won Academy Award for Best Short Film (Animated) |
| Pierrepoint | Adrian Shergold | Timothy Spall, Juliet Stevenson | Drama | |
| Played | Sean Stanek | Val Kilmer, Mick Rossi | Crime | |
| The Queen | Stephen Frears | Helen Mirren, Michael Sheen | Drama | Winner of the Academy Award and Golden Globe for Best Actress and BAFTA for Best Film and Best Actress. |
| Red Road | Andrea Arnold | Kate Dickie, Tony Curran, Martin Compston, Natalie Press | Thriller | Won the Jury Prize at the 2006 Cannes Film Festival |
| Scenes of a Sexual Nature | Ed Blum | Holly Aird, Eileen Atkins | Comedy/Drama | |
| Scoop | Woody Allen | Woody Allen, Scarlett Johansson, Hugh Jackman, Ian McShane | Romantic Comedy/Mystery | |
| Stormbreaker | Geoffrey Sax | Alex Pettyfer, Mickey Rourke | Adventure | |
| Tirant lo Blanc | Vicente Aranda | Victoria Abril, Leonor Watling, Jane Asher | Adventure | Co-production with Italy and Spain |
| The Thief Lord | Richard Claus | Aaron Taylor-Johnson, Rollo Weeks, Vanessa Redgrave | Adventure | British-German co-production |
| Three | Stewart Raffill | Billy Zane, Kelly Brook | Drama | |
| United 93 | Paul Greengrass | J.J. Johnson, Gary Commock, Polly Adams | Drama | Winner of BAFTA for Best Director |
| Venus | Roger Michell | Peter O'Toole, Leslie Phillips | Drama | |
| Wild Country | Craig Strachan | Martin Compston, Peter Capaldi, Samantha Shields | Horror | |
| The Wind That Shakes the Barley | Ken Loach | Cillian Murphy, Padraic Delaney | War | |
| A Woman in Winter | Richard Jobson | Jamie Sives, Julie Gayet | Drama | |
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