Leucyl-tRNA synthetase

LARS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases LARS, HSPC192, LARS1, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, ILFS1, Leucyl-tRNA synthetase
External IDs MGI: 1913808 HomoloGene: 7083 GeneCards: LARS
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

51520

107045

Ensembl

ENSG00000133706

ENSMUSG00000024493

UniProt

Q9P2J5

Q8BMJ2

RefSeq (mRNA)

NM_020117
NM_001317964
NM_001317965
NM_016460

NM_134137

RefSeq (protein)

NP_064502.9
NP_001304893.1
NP_001304894.1
NP_057544.2

NP_598898.2

Location (UCSC) Chr 5: 146.11 – 146.18 Mb Chr 18: 42.2 – 42.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.[3][4]

Function

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.[4]

Interactions

Leucyl-tRNA synthetase has been shown to interact with EEF1G.[5]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Giles RE, Shimizu N, Ruddle FH (Jan 1981). "Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells". Somatic Cell Genet. 6 (5): 667–687. doi:10.1007/BF01538645. PMID 6933703.
  4. 1 2 "Entrez Gene: LARS leucyl-tRNA synthetase".
  5. Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.

Further reading


This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.