Lactoferricin

Lactoferricin
Identifiers
Symbol N/A
OPM superfamily 226
OPM protein 1lfc

Lactoferricin is an amphipathic, cationic peptide with anti-microbial[1] and anti-cancer[2] properties. It can be generated by the pepsin-mediated digestion of lactoferrin.

Lactoferricin is the most studied AMP derived from milk protein. The complete sequence of lactoferricin corresponds to lactoferrin fragment 17-41 (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084) and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural, synthetic and modified) comprising or derived from the complete lactoferricin.[3] In humans, lactoferricin corresponds to lactoferrin fragment 1-47 but consists of two subunits, namely fragments 1-11 and 12-47 (LFH0009), connected by a disulfide bridge.

References

  1. ↑ Wakabayashi H, Takase M, Tomita M. Lactoferricin derived from milk protein lactoferrin. Curr Pharm Des. 2003;9(16):1277-87.
  2. ↑ Eliassen LT, Berge G, Sveinbjornsson B, Svendsen JS, Vorland LH, Rekdal O. Evidence for a direct antitumor mechanism of action of Bovine lactoferricin. Anticancer Res. 2002 Sep-Oct;22(5):2703-10.
  3. ↑ Jérémie Théolier, Ismail Fliss, Julie Jean, Riadh Hammami"MilkAMP: a comprehensive database of antimicrobial peptides of dairy origin". Dairy Science & Technology. 94: 181–193. 2013. doi:10.1007/s13594-013-0153-2.


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