LGALS9

LGALS9
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV6
Identifiers
Aliases	LGALS9, HUAT, LGALS9A, galectin 9
External IDs	HomoloGene: 32078 GeneCards: LGALS9
Gene ontology Molecular function • galactose binding • signal transducer activity • enzyme binding • disaccharide binding • carbohydrate binding Cellular component • intracellular • extracellular space • extracellular region • extracellular exosome • cytoplasm • nucleus Biological process • cellular response to virus • negative regulation of interferon-gamma production • response to interleukin-1 • positive regulation of interleukin-6 secretion • toll-like receptor 4 signaling pathway • maternal process involved in female pregnancy • positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • immune system process • positive regulation of CD4-positive, alpha-beta T cell proliferation • ERK1 and ERK2 cascade • female pregnancy • positive regulation of viral entry into host cell • positive regulation of monocyte chemotactic protein-1 production • natural killer cell tolerance induction • negative regulation of chemokine production • regulation of interleukin-5 production • toll-like receptor 2 signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of mast cell degranulation • negative regulation of gene expression • positive regulation of interleukin-4 production • chemotaxis • negative regulation of activated T cell proliferation • regulation of interleukin-4 production • positive regulation of interleukin-12 secretion • response to lipopolysaccharide • positive regulation of gene expression • positive regulation of NF-kappaB transcription factor activity • positive regulation of interferon-gamma secretion • positive regulation of interleukin-13 secretion • positive regulation of interleukin-1 beta secretion • positive regulation of dendritic cell apoptotic process • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • positive regulation of I-kappaB kinase/NF-kappaB signaling • p38MAPK cascade • negative regulation of natural killer cell mediated cytotoxicity • positive regulation of transforming growth factor beta production • positive regulation of interleukin-8 secretion • negative regulation of CD4-positive, alpha-beta T cell proliferation • positive regulation of dendritic cell differentiation • negative regulation of tumor necrosis factor production • positive regulation of NF-kappaB import into nucleus • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response • inflammatory response • regulation of p38MAPK cascade • positive regulation of tumor necrosis factor secretion • mature conventional dendritic cell differentiation • positive regulation of dendritic cell chemotaxis • positive regulation of activated T cell autonomous cell death • positive regulation of interleukin-10 secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3965	n/a
Ensembl	ENSG00000168961	n/a
UniProt	O00182	n/a
RefSeq (mRNA)	NM_002308 NM_009587	n/a
RefSeq (protein)	NP_002299.2 NP_033665.1	n/a
Location (UCSC)	Chr 17: 27.63 – 27.65 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Galectin-9 is a protein that in humans is encoded by the LGALS9 gene.^[2][3]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. This galectin is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. The protein has N- and C- terminal carbohydrate-binding domains connected by a link peptide. Multiple alternatively spliced transcript variants have been found for this gene.^[3]

References

Further reading